Uni Research, Centre for applied biotechnology, offers a three-year PhD-position in diarrheal disease vaccine development. The position is linked to the project Development of a vaccine for enterotoxigenic E. coli based on the heat-stable toxin (ETECvac), funded by the GLOBVAC programme of the Research Council of Norway.
Enterotoxigenic E. coli (ETEC) expressing the heat-stable toxin (ST) is among the most important causes of diarrheal disease in children less than five years of age in low and lower middle income countries. Diarrhea causes ill health and malnutrition, and is the second most common cause of death among children. Currently available prototype ETEC vaccines target colonization factors and the heat-labile toxin, but not ST. They have so far failed to confer adequate protection, and development of an ST-based vaccine has a high priority.
The ETECvac project is based on a unique and comprehensive ST mutational library, established at the University of Bergen (UiB) and Uni Research, which allows an unprecedented detailed study of the toxin's properties. The main aims of the ETECvac project are to design safe and protective ST vaccine candidates, and to establish the first human challenge model for estimating the protective efficacy of an ST vaccine.
The research will be conducted at UiB and Uni Research, in close collaboration with partners at Institut Pasteur, Paris, France, and Indian Institute of Science, Bangalore, India.
Applicants must have completed a master's degree or equivalent in molecular biology, biochemistry, vaccinology or other relevant field, or have submitted the master's thesis for evaluation before the application deadline. It is a requirement that the master’s degree has been completed and that you meet the criteria for admission to the PhD study programme at the University of Bergen, before the decision to appoint can be made. We are looking for candidates with experience with recombinant technologies and protein expression/purification. Experience with research relevant for the project, and techniques such as chemical cross-linking, NMR, and cell culture systems will be considered an advantage. The candidate must be able to work independently and in a team, have good communicational and organizational skills, be highly motivated, and have ambitions to become a strong scientist.
To read more and apply, please click here.